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Overall, metabolic reprogramming is essential for both the inflammatory and anti-inflammatory response in immune cells, with aerobic glycolysis being predominant in inflammatory processes, while OXPHOS is more related to the anti-inflammatory response ( Figure 1 LDH is a nicotinamide adenine dinucleotide (NAD+) dependent enzyme that mediates the bidirectional conversion of pyruvate and lactate concomitantly with the oxidation and reduction of the cofactor NAD+